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研究業績

Recent Publications

2024年

  • Lysophospholipase D activity on oral mucosa cells in whole mixed human saliva involves in production of bioactive lysophosphatidic acid from lysophosphatidylcholine. Tsutsumi T, Taira S, Matsuda T, Kageyama C, Wada M, Kitayama T, Morioka N, Morita K, Tsuboi K, Yamazaki N, Kido J, Nagata T, Dohi T, Tokumura A. Prostaglandins & Other Lipid Mediators 174:106881 2024年8月 https://doi.org/10.1016/j.prostaglandins.2024.106881

  • GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression. Okamoto Y, Kitakaze K, Takenouchi Y, Matsui R, Koga D, Miyashima R, Ishimaru H, Tsuboi K. Biochimica et Biophysica Acta - Molecular Cell Research 1871(7):119798 2024年7月 https://doi.org/10.1016/j.bbamcr.2024.119798

  • L-NAME誘発性高血圧ラットの内皮機能不全と心臓リモデリングに対する魚油摂取の効果. 薗田邦博, 河野有華, 大竹一男, 竹之内康広, 柴祥子, 小林順, 加園恵三. 金城学院大学消費生活科学研究所紀要 28(1):13-28 2024年3月 https://kinjo.repo.nii.ac.jp/records/2000131

  • Sweat protects against contact hypersensitivity: Transient sweat suppression compromises skin barrier function in mice. Ishimaru H, Nakamoto K, Yamane M, Yamamoto T, Kitakaze K, Takenouchi Y, Tsuboi K, Okamoto Y, Aoyama Y. Journal of Investigative Dermatology 144(10):2211-2220.e6 2024年3月 https://doi.org/10.1016/j.jid.2024.02.025

  • A fluorogenic substrate for the detection of lipid amidases in intact cells. Casasampere M, Ung J, Iñáñez A, Duffau C, Tsuboi K, Casas J, Tan SF, Feith DJ, Andrieu-Abadie N, Segui B, Loughran TP Jr, Abad JL, Fabrias G. Journal of Lipid Research 65(3):100520 2024年2月 https://doi.org/10.1016/j.jlr.2024.100520

2023年

  • Genetic ablation of Saposin-D in Krabbe disease eliminates psychosine accumulation but does not significantly improve demyelination. Watanabe T, Tsuboi K, Matsuda N, Ishizuka Y, Go S, Watanabe E, Ono A, Okamoto Y, Matsuda J. Journal of Neurochemistry 166(4):720-746 2023年6月 https://doi.org/10.1111/jnc.15876

  • GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator. Kitakaze K, Ali H, Kimoto R, Takenouchi Y, Ishimaru H, Yamashita A, Ueda N, Tanaka T, Okamoto Y, Tsuboi K. Communications Biology 6:524 2023年5月 https://doi.org/10.1038/s42003-023-04900-4

2022年

  • 蛍光基質を用いた簡便なグリセロホスホジエステラーゼGDE4およびGDE7の活性測定法. 北風圭介, 坪井一人. 生化学 94(6): 923-927 2022年12月 https://doi.org/10.14952/SEIKAGAKU.2022.940923

  • Assay of NAAA activity. Tsuboi K, Ueda N. Methods in Molecular Biology Vol. 2576. Endocannabinoid Signaling: Methods and Protocols 2nd Edition 261-274 Maccarrone M (Ed), Humana Press, New York 2022年9月 https://doi.org/10.1007/978-1-0716-2728-0_22

  • Herpes simplex virus-induced murine dry skin model through sweating disturbance. Asanuma Y, Ishimaru H,  Sato T, Yamamoto T, Aoyama Y. Journal of Dermatological Science 107(3):151-159 2022年9月 https://doi.org/10.1016/j.jdermsci.2022.09.001

  • Effects of dietary palmitoleic acid on vascular function in aorta of diabetic mice. Takenouchi Y, Seki Y, Shiba S, Ohtake K, Nobe K, Kasono K. BMC Endocrine Disorders 22:103 2022年4月 https://doi.org/10.1186/s12902-022-01018-2

2021年

  • Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner. Okamoto S, Miyano K, Kitakaze K, Kato H, Yamauchi A, Kajikawa M, Itsumi M, Kawai C, Kuribayashi F. Biochemical and Biophysical Research Communications 587 78-84 2021年11月 https://doi.org/10.1016/j.bbrc.2021.11.090

  • Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7. Kitakaze K, Tsuboi K, Tsuda M, Takenouchi Y, Ishimaru H, Okamoto Y. Journal of Lipid Research  62 100141 2021年10月  https://doi.org/10.1016/j.jlr.2021.100141 

  • Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation. Okamoto Y, Kitakaze K, Takenouchi Y, Yamamoto S, Ishimaru H, Tsuboi K. Cellular Signalling 88 110156 2021年9月  https://doi.org/10.1016/j.cellsig.2021.110156

  • ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model. Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, Inagaki M, Tachikawa M, Fujitani Y, Okamoto Y, Oyadomari S. Molecular Metabolism 54 101338 2021年9月  https://doi.org/10.1016/j.molmet.2021.101338 

  • Involvement of the γ isoform of cPLA2 in the biosynthesis of bioactive N-acylethanolamines. Guo Y, Uyama T, Rahman SMK, Sikder MM, Hussain Z, Tsuboi K, Miyake M, Ueda N. Molecules 26(17) 5213-5213 2021年8月  https://doi.org/10.3390/molecules26175213

  • Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells. Taniai T, Shirai Y, Shimada Y, Hamura R, Yanagaki M, Takada N, Horiuchi T, Haruki K, Furukawa K, Uwagawa T, Tsuboi K, Okamoto Y, Shimada S, Tanaka S, Ohashi T, Ikegami T. Cancer Science 112(11):4570-4579 2021年8月  https://doi.org/10.1111/cas.15123

  • 3.3 不飽和脂肪酸, 3.3.3 生理学. 坪井一人. ビタミン・バイオファクター総合事典 327-332, 日本ビタミン学会（編）, 朝倉書店,  東京 2021年6月  http://www.asakura.co.jp/books/isbn/978-4-254-10292-5/

  • Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines. Tsuboi K, Tai T, Yamashita R, Ali H, Watanabe T, Uyama T, Okamoto Y, Kitakaze K, Takenouchi Y, Go S, Rahman IAS, Houchi H, Tanaka T, Okamoto Y, Tokumura A, Matsuda J, Ueda N. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1866(9) 158972 2021年5月  https://doi.org/10.1016/j.bbalip.2021.158972

2020年

  • Inhibition of NAPE-PLD activity by natural compounds and synthetic drugs, and its biological relevance. Tsuboi K, Uyama T, Ueda N. Drug Discovery Series No. 76. New tools to interrogate endocannabinoid signalling–from natural compounds to synthetic drugs 301-336, Maccarrone M (Ed), Royal Society of Chemistry, Cambridge 2020年11月   https://doi.org/10.1039/9781839160752-00301

  • N-アシルエタノールアミンの機能と生合成機構. 坪井一人, 宇山徹, 上田夏生. 生化学 92(5) 666-679 2020年10月    https://doi.org/10.14952/SEIKAGAKU.2020.920666

  • 低酸素環境下トレーニングでの魚油濃縮物摂取によるヘモレオロジー的検討. 櫛部静二, 小林悟, 新井尚之, 浜崎景, 野部浩司, 竹之内康広, 柴祥子, 大竹一男, 白幡晶, 加園恵三. 脂質栄養学 29(2):127-135 2020年9月 https://doi.org/10.4010/jln.29.127

  • Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts. Takenouchi Y, Kitakaze K, Tsuboi K, Okamoto Y. Experimental Cell Research 391(2) 112010 2020年6月  https://doi.org/10.1016/j.yexcr.2020.112010

2019年

  • Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity. Kitakaze K, Taniuchi S, Kawano E, Hamada Y, Miyake M, Oyadomari M, Kojima H, Kosako H, Kuribara T, Yoshida S, Hosoya T, Oyadomari S. eLife 8 e43302 2019年12月  https://doi.org/10.7554/eLife.43302

  • Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation. Ishimaru K, Yoshioka K, Kano K, Kurano M, Saigusa D, Aoki J, Yatomi Y, Takuwa N, Okamoto Y, Proia RL, Takuwa Y. Scientific Reports 9(1) 18329-18329 2019年12月  https://doi.org/10.1038/s41598-019-54877-6

  • Chronic treatment with alpha-lipoic acid improves endothelium-dependent vasorelaxation of aortas in high-fat diet-fed mice. Takenouchi Y, Tsuboi K, Ohsuka K, Nobe K, Ohtake K, Okamoto Y, Kasono K. Biological and Pharmaceutical Bulletin 42(9) 1456-1463 2019年9月  https://doi.org/10.1248/bpb.b18-00800

  • Intracellular Ca2+-dependent formation of N-acyl-phosphatidylethanolamines by human cytosolic phospholipase A2ε. Binte Mustafiz SS, Uyama T, Morito K, Takahashi N, Kawai K, Hussain Z, Tsuboi K, Araki N, Yamamoto K, Tanaka T, Ueda N. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1864(12) 158515 2019年8月  https://doi.org/10.1016/j.bbalip.2019.158515

2018年

  • The role of intracellular anionic phospholipids in the production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε. Binte Mustafiz SS, Uyama T, Hussain Z, Kawai K, Tsuboi K, Araki N, Ueda N. The Journal of Biochemistry 165(4) 343-352 2018年12月  https://doi.org/10.1093/jb/mvy104

  • Class II PI3K α and β are required for Rho-dependent uterine smooth muscle contraction and parturition in mice. Sarker MAK, Aki S, Yoshioka K, Kuno K, Okamoto Y, Ishimaru K, Takuwa N, Takuwa Y. Endocrinology 2018年11月  https://doi.org/10.1210/en.2018-00756

  • Endocannabinoids and related N-acylethanolamines: biological activities and metabolism. Tsuboi K, Uyama T, Okamoto Y, Ueda N. Inflammation and Regeneration 38 28 2018年10月  https://doi.org/10.1186/s41232-018-0086-5

  • Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice. Takenouchi Y, Ohtake K, Nobe K, Kasono K. Lipids in Health and Disease 17(1) 118 2018年5月  https://doi.org/10.1186/s12944-018-0770-0

  • Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages. Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y. PLoS One 13(5) e0197604 2018年5月  https://doi.org/10.1371/journal.pone.0197604

  • Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca2+-dependent N-acyltransferase. Hussain Z, Uyama T, Kawai K, Binte Mustafiz SS, Tsuboi K, Araki N, Ueda N. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1863(5) 493-502 2018年2月  https://doi.org/10.1016/j.bbalip.2018.02.002

  • The biosynthetic pathways of N-acylethanolamines in mammals. Binte Mustafiz SS, Uyama T, Hussain Z, Tsuboi K, Ueda N. eLS A27711 2018年1月  https://doi.org/10.1002/9780470015902.a0027711

2017年

  • Mammalian enzymes responsible for the biosynthesis of N-acylethanolamines. Hussain Z, Uyama T, Tsuboi K, Ueda N. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1862(12) 1546-1561 2017年8月  https://doi.org/10.1016/j.bbalip.2017.08.006

  • Peripheral tissue levels and molecular species compositions of N-acyl-phosphatidylethanolamine and its metabolites in mice lacking N-acyl-phosphatidylethanolamine-specific phospholipase D. Inoue M, Tsuboi K, Okamoto Y, Hidaka M, Uyama T, Tsutsumi T, Tanaka T, Ueda N, Tokumura A. The Journal of Biochemistry 162(6) 449-458 2017年8月  https://doi.org/10.1093/jb/mvx054

  • An involvement of phospholipase A/acyltransferase family proteins in peroxisome regulation and plasmalogen metabolism. Uyama T, Tsuboi K, Ueda N. FEBS Letters 591(18) 2745-2760 2017年8月  https://doi.org/10.1002/1873-3468.12787

  • Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6. Ohkura S, Usui S, Takashima S, Takuwa N, Yoshioka K, Okamoto Y, Inagaki Y, Sugimoto N, Kitano T, Takamura M, Wada T, Kaneko S, Takuwa Y. PLOS ONE 12(8) e0182329 2017年8月  https://doi.org/10.1371/journal.pone.0182329

  • グリセロホスホジエステラーゼ・ファミリーによるN-アシルエタノールアミンおよびリゾホスファチジン酸の生成. 坪井一人, 宇山徹, 上田夏生. ビタミン 91(8):489-496 2017年8月 https://doi.org/10.20632/vso.91.8_489

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